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Suresh, R.
- Chemo Preventive Activity of Triumfetta rhomboidea in 7, 12-Dimethylbenz (A) Anthracene Induced Breast Cancer in Sprague–Dawley Rat Model
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Affiliations
1 Department of Pharmacology, RVS College of Pharmaceutical Sciences, Sulur, Coimbatore-641402, IN
2 RVS College of Pharmaceutical Sciences, Sulur, Coimbatore-641402, IN
3 Department of Pharmaceutics, RVS College of Pharmaceutical Sciences, Sulur, Coimbatore-641402, IN
1 Department of Pharmacology, RVS College of Pharmaceutical Sciences, Sulur, Coimbatore-641402, IN
2 RVS College of Pharmaceutical Sciences, Sulur, Coimbatore-641402, IN
3 Department of Pharmaceutics, RVS College of Pharmaceutical Sciences, Sulur, Coimbatore-641402, IN
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Research Journal of Pharmacy and Technology, Vol 10, No 3 (2017), Pagination: 687-692Abstract
The chemopreventive potential was assessed by monitoring the tumour incidence, total no of tumours and tumour volume and also by analyzing the level of biochemical markers such as 17-β estradiol (E2), TBARS and antioxidants during DMBA induced mammary carcinoma. A single subcutaneous injection of DMBA (25mg/kg) produced mammary carcinoma in female Sprague-Dawley rats. Oral administration of 100mg/kg and 200mg/kg of TRM to DMBA treated rats significantly prevented the tumour incidence, total no of tumours, tumour volume and brought back the above said biochemical markers to normal. The present study confirmed the chemopreventive activity of leaves of Triumfetta rhomboidea in mammary carcinomaKeywords
Mammary Carcinoma, Triumfetta rhomboidea, Leaves, DMBA, Antioxidants.- Screening of In vitro Antioxidant Activity of Methanolic extract of Maruthampattai kudineer- A Siddha Polyherbal Preparation
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Authors
Affiliations
1 Dept. of Sirappu Maruthuvam, National Institute of Siddha, Chennai-47, IN
2 Central Council for Research in Siddha, Chennai-47, IN
3 Greensmed Labs, Thoraipakkam, Chennai -600097, IN
4 National Institute of Siddha, Chennai-47, IN
1 Dept. of Sirappu Maruthuvam, National Institute of Siddha, Chennai-47, IN
2 Central Council for Research in Siddha, Chennai-47, IN
3 Greensmed Labs, Thoraipakkam, Chennai -600097, IN
4 National Institute of Siddha, Chennai-47, IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 1 (2019), Pagination: 219-222Abstract
Siddha medical system is one of the renowned traditional system of India which is gaining popularity in recent days. Therefore scientific documentation of the siddha formulations has become the need of the hour. The aim of the study was to evaluate in vitro antioxidant potential of methanolic extract of Maruthampattai kudineer, a polyherbal siddha formulation indicated in siddha text for the management of diabetes. One of the major causative factor implicated is the damage induced by free radicals in the development of diabetes and its complications and hence an antidiabetic compound with antioxidant properties would be more favourable. Therefore, the anti-oxidant properties of this formula were studied by using 2, 2- diphenyl-1-picryl-hydrazyl (DPPH) assay, reducing power activity and [2, 2’-azino-bis (3- ethylbenzthiazoline-6-sulphonic acid)] ABTS assay.Keywords
Siddha, Maruthampattai Kudineer, Anti-Oxidant Properties.References
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